CONFERENCE SERIES: Clinical Trials & Translational Medicine
Recorded at: PEGS: The Essential Protein Engineering Summit

Digital Course: Translational Strategies for Development of Monoclonal Antibodies from Discovery to the Clinic http://www.chidb.com/bioteam//UploadedImages/PEGS/images/button.jpg     

About this Product:
The effective information flow and translation of accumulated knowledge across various antibody development stages remain a major challenge. Successful strategies for development of monoclonal antibodies require integration of relevant knowledge with respect to target antigen properties, antibody design criteria such as affinity, isotype selection, pharmacokinetic (PK)-pharmacodynamic (PD) properties, and antibody cross-reactivity across species from the early stages of antibody development. Biophysical measurements are one of the critical components necessary for the design of effective translational strategies for lead selection and evaluation of the relevant animal species for preclinical safety and efficacy studies. Incorporation of effective translational strategies from the early stages of the antibody development process is a necessity; when considered it not only reduces development time and cost, but also fosters implementation of rational decision making throughout all phases of antibody development.
 

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About this Product:
The 180 minute digital course includes 4 presentations perfectly synchronized with power point slides.

Presentations and Instructors: 

Translation of Exposure-Response Data from Discovery to the Clinic in Support of FIH Dosing

Mohammad Tabrizi, Ph.D., Director, Global PK-PD and Bioanalysis, MedImmune, Hayward CA
 


Considerations for Preclinical Development of Monoclonal Antibodies
Gadi Bornstein, Ph.D., Principal Scientist, AstraZeneca R&D Boston
 

How Do We Measure Affinity

Scott L. Klakamp PhD, Research Fellow, Biophysical Chemistry and Research Informatics, Takeda San Francisco
 


CONFERENCE SERIES: Biological Therapeutic Products
Recorded at: PEGS: The Essential Protein Engineering Summit

Digital Course: Phage and Yeast Display Libraries and their Screening                                                                 http://www.chidb.com/bioteam//UploadedImages/PEGS/images/button.jpg 

About this Product:

 This digital course is meant to bring scientists up to speed on the display technologies covered by the main  
 conference. The course will provide an overview of:
 

  • Phage display and construction of phage-displayed peptide, scFv and Fab libraries
  • Yeast display and construction of yeast-displayed scFv and Fab libraries
  • Screening technologies that are compatible with phage- vs. yeast-display libraries

 

Presentations and Instructors: 

Phage-display Library Construction and Screening

Jamie Kathleen Scott, M.D., Ph.D., Professor and Canada Research Chair in Molecular Immunity, Department of Molecular Biology & Biochemistry and Faculty of Health Sciences, Simon Fraser University
 

Display Technologies for Making Therapeutic Antibodies

James D. Marks, M.D., Ph.D., Professor of Anesthesia and Pharmaceutical Chemistry, Chief of Anesthesia, San Francisco General Hospital, Vice Chairman, Dept. of Anesthesia and Perioperative Care, University of California, San Francisco and San Francisco General Hospital
 

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     About this Product:
     The 176 minute digital course includes 2 presentations perfectly     
     synchronized with power point slides.