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Sunday, April
27 2:00 - 5:00pm
(SC1) Protein Folding, Re-Folding and Aggregation*
Course Instructors:
Theodore W. Randolph, Ph.D., Gillespie Professor, Center for Pharmaceutical
Biotechnology Co-Director, University of Colorado (invited)
Carlos N. Pace, Ph.D., Texas A and M University
Paul Ramage, Ph.D., Novartis
Institutes for BioMedical Research
Protein Folding
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Thermodynamic forces that
fold proteins (hydrogen bonds
vs. hydrophobic effects)
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Kinetics of protein folding
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Analytical methods to monitor protein
folding
Protein Aggregation
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Colloidal and thermodynamic protein
stability
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Basic formulation strategies
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Analytical methods for monitoring
protein aggregation
Protein Refolding
(SC3)
Phage and Yeast Display Library Screening for the Novice*
Presenters:
Jamie Kathleen Scott, M.D., Ph.D.,
Simon Fraser University
Andrew M. Bradbury, M.B. B.S.,
Ph.D., Los Alamos National Laboratory
James D. Marks,
M.D., Ph.D., University of California, San Francisco
This workshop is meant to bring the novice up to speed
on the display technologies covered by the main
conference. The workshop will provide an
overview of:
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Phage display and construction of phage-displayed
peptide, scFv and Fab libraries
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Yeast display and construction of yeast-displayed
scFv and Fab libraries
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Screening technologies that are compatible with
phage- vs. yeast-display libraries
*Separate Registration Required
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Monday, April
28
9:00am - 12:00pm
(SC2) Preclinical Development Antibodies*
Course Instructors:
Mohammad Tabrizi, Ph.D., Director, MedImmune
Scott Klalamp, Ph.D., Principal Scientist, MedImmune
Gadi Bornstein, Ph.D., Principal Scientist, AstraZeneca R&D
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Affinity Determination: Why Does
It Matter, How Can It Impact Your Clinical Dose Selection?
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How Do We Measure Affinity and
the Challenges
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Pharmacokinetics and
Pharmacodynamics of Antibodies
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Preclinical Development of
Antibodies
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PROBLEM-SOLVING BREAK-OUT
SESSIONS
Break-out
Sessions are one hour group
discussions focused on a particular topic. This is
a moderated discussion
with brainstorming and interactive
problem solving amongst scientists
from diverse areas who share
a common interest in the discussion
topic.
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