Whether for therapeutics, diagnostics or for characterization, some proteins just don’t cooperate when it comes to expression. CHI’s Tenth Annual Difficult to Express Proteins conference will present the most up-to-date strategies and technologies for successfully expressing the proteins that keep researchers up at night. Folding problems, toxicity to hosts, purification issues or any of a host of other problems make these proteins resist standard expression and purification methods. Difficult to Express Proteins presents solutions and strategies to tame these “finicky” proteins.

Topics to be covered include, but are not limited to:

Methods and Technologies for Overcoming Difficult to Express Proteins, such as:

  • Refolding strategies
  • Novel hosts and vectors
  • Salvage methods to achieve expression in hosts formerly unable to do so
  • Strategies for improving the yields of proteins for structural studies
  • Chaperones, fusion proteins, and expression partners
  • Enhanced genes, engineered metabolic pathways, transcriptional engineering

Discovery & Development Tools

  • Better, more capable expression assays and assay interpreters
  • Case studies of successful and failed expression strategies

New Data in the Basic Science

  • How new discoveries in protein science change the landscape of protein expression

Scientists who wish to present their knowledge and expertise to their colleagues are asked to click here to submit an abstract. Remember to specify the conference that you are interested in and please provide your full contact information.

Deadline for submission is Friday, September 25, 2015.

All proposals are subject to review by the Scientific Advisory Committee to ensure the highest quality of the Conference Program. Please note that due to limited speaking slots, preference is given to pharmaceutical and biotech companies, regulators and those from academia. Additionally, vendors/consultants who provide products and services to these biopharmaceutical companies are offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

For more details on the conference, please contact:

For partnering and sponsorship information, please contact:

Elizabeth J. Lamb
Senior Conference Director
Cambridge Healthtech Institute
T: 781-247-6259
E: elamb@healthtech.com

Jason Gerardi
(Companies A-K)
Manager, Business Development
Cambridge Healthtech Institute
T: 781-972-5452
E: jgerardi@healthtech.com

Carol Dinerstein
(Companies L-Z)
Director, Business Development
Cambridge Healthtech Institute
T: 781.972.5471
E: dinerstein@healthtech.com