Cambridge Healthtech Institute’s Seventeenth Annual
Phage and Yeast Display of Antibodies
Innovating Molecular Evolution
Part of the 11th Annual PEGS: the essential protein engineering summit
May 4-5, 2015 | World Trade Center | Boston, Massachusetts


The biologics market is being driven by innovation in design and diversity of biologic molecules. Directed evolution of biologics is critical to generating and screening an array of novel constructs for the right activity and properties. This conference will provide a review of the newest tools essential for antibody engineering. Leaders in the field will showcase the latest trends in technologies and approaches for creating the next generation of drug candidates.


KEYNOTE SESSION

Phage Display to Generate Binders against Immune Blockers

K. Dane Wittrup, Ph.D., J.R. Mares Professor, Chemical Engineering & Bioengineering, Massachusetts Institute of Technology

The Rise of Bispecific Antibodies as Therapeutics

Paul J. Carter, Staff Scientist and Senior Director, Antibody Engineering, Genentech, Inc.


NOVEL LIBRARIES

Construction and Use of Large Antibody Libraries in Mammalian Cells

John McCafferty, Ph.D., CEO and Founder, IONTAS Ltd.

Engineering Cow Ultra-Long CDR3 Antibodies

Vaughn Smider, M.D., Ph.D., Assistant Professor, Cell & Molecular Biology, Scripps Research Institute

Phage Selection of Light-Responsive Ligands

Christian Heinis, Ph.D., Professor, Institute of Chemical Sciences and Engineering (ISIC), Ecole Polytechnique Federale de Lausanne (EPFL)

Towards a New Class of Bio-Therapeutics based on Synthetic Genetic Polymers

Philipp Holliger, Ph.D., Program Leader, MRC Laboratory of Molecular Biology

Novel Prolonged CDR3 Library

David Lowe, Ph.D., Director, R&D, Antibody Discovery and Protein Engineering, MedImmune Ltd.

Antibody Library Display on a Mammalian Virus: Combining the Advantages of Panning and Cell Sorting in One Technology

Ernest S. Smith, Ph.D., Senior Vice President, Research & CSO, Vaccinex, Inc.


ANTIBODIES AGAINST INFECTIOUS DISEASE

Engineering Neutralizing Antibodies to Guide Vaccine Design

William R. Schief, Ph.D., Professor, Immunology & Microbial Science, Scripps Research Institute; Director, Vaccine Design, International AIDS Vaccine Initiative

Synthetic Antibodies for Ebola Virus Immunotherapy and Research

Jonathan Lai, Ph.D., Associate Professor, Biochemistry, Albert Einstein College of Medicine


INNOVATIVE SCAFFOLDS AND NEW TECHNOLOGIES

Engineering a Rationally-Identified 5 KDA Protein Scaffold for Molecular Imaging

Benjamin J. Hackel, Ph.D., Assistant Professor, Chemical Engineering and Materials Science, University of Minnesota

Zymogen Activator Peptides Selected by Phage Display

Robert A. Lazarus, Ph.D., Principal Scientist, Early Discovery Biochemistry, Genentech, Inc.

HT Screening Platform, Screen Functional Activity and Binding

Jennifer Cochran, Ph.D., Hitachi America Associate Professor, Bioengineering and Chemical Engineering, Stanford University


PHAGE VS. CELLS

Phage Conjugated to Various Enzymes

Jennifer Cha, Ph.D., Norviel Associate Professor, Chemical and Biological Engineering, Colorado State

Mining for Tumor Targeting Peptides-New Ligands for Molecular Imaging & Personalized Therapies

Kathlynn C. Brown, Ph.D., Program Director, Center for Chemical Biology, SRI International

Phage vs. Cells

Bin Liu, Ph.D., Professor, Anesthesia, University of California, San Francisco


COMBINING IN SILICO ANALYSIS WITH DISPLAY

Computational Design of CDR Loop Using Yeast Display to Select and Refine Candidates

Yanay Ofran, Ph.D., Principal Investigator, Systems Biology & Functional Genomics, Bar Ilan University; Founder, Biolojic Design Ltd.

Design and Use of Hyper-Stable Synthetic Human Antibody Libraries

Pierre Martineau, Ph.D., Group Leader, IRCM, INSERM



For more details on the conference, please contact:
Christina Lingham
Executive Director, Conferences
Cambridge Healthtech Institute
T: 781-972-5464
E: clingham@healthtech.com 

For partnering and sponsorship information, please contact:
Jason Gerardi (Companies A-K)
Manager, Business Development
Cambridge Healthtech Institute
T: 781-972-5452
E: jgerardi@healthtech.com 

Carol Dinerstein (Companies L-Z)
Director, Business Development
Cambridge Healthtech Institute
T: 781.972.5471
E: dinerstein@healthtech.com