Cambridge Healthtech Institute’s Fourth Annual
Optimizing Protein Expression
Enhancing Expression Systems
Part of the Tenth Annual PEGS: the essential protein engineering summit
May 7-8, 2014 | Seaport World Trade Center| Boston, MA
When expressing proteins, there are a variety of expression systems to choose from. CHO is seen as the ‘king’ in the industry, but does it meet all needs of rapid production and budget constraints? This meeting will explore “Optimizing Protein Expression” through understanding and enhancing expression systems, and will especially focus on CHO cells and other mammalian systems, E.coli and baculovirus. Other host systems, such as yeast and algae, will be touched on as well.
Along with case studies, the meeting will feature experts who reveal the underlying mechanisms and insights into the varying systems in order to enhance protein expression. Comparing and contrasting systems will also be featured to provide greater understanding of how these systems function within the context of the results achieved. Learn the latest protocols and see how protein science leaders are enhancing expression systems to reach greater productivity.
The Production of Complex Proteins in Drug Discovery: Challenges & Solutions
René Assenberg, Ph.D., Research Investigator, Novartis Pharma AG
Protein Expression Technologies - Evolution or Revolution?
Lorenz Mayr, Ph.D., Vice President & Global Head, Reagents & Assay Development, AstraZeneca
Cell-Free Protein Expression Based on Extracts from
Stefan Kubick, Ph.D., Group Manager, Cell Free Protein Synthesis, Fraunhofer Institut fur Biomedizinische Technik IBMT
Engineering Recombinant Proteins for Improved Manufacturability in CHO Cells
Sujeewa Wijesuriya, Ph.D., Senior Scientist, XOMA LLC
Estimation of Metabolic Rewiring in CHO Cell Culture Using Combined 13C-Metabolic Flux Analysis
Woo Suk Ahn, Ph.D., Senior Scientist, Laboratory for Bioinformatics and Metabolic Engineering, Massachusetts Institute of Technology
Impact of Aeration Strategy on CHO Cell Performance during Antibody Production
Daniel G. Bracewell, Ph.D., Reader, Biochemical Engineering, University College London
A Novel Baculovirus Vector for Production of Non-Fucosylated Recombinant Glycoproteins
Don Jarvis, Ph.D., Professor, Molecular Biology, University of Wyoming
Insect Cell Culture for Rapid GMP Manufacturing of Seasonal and Pandemic Influenza Vaccines
Nikolai Khramtsov, Ph.D., Associate Director, Upstream Development, Product Realization, Protein Sciences Corp.
Optimizing Protein Expression with the Three Ss of Cell Free Protein Synthesis – Simplicity, Speed, and Scalability
Stuart Bussell, Ph.D., Director, Upstream Process Development, Sutro Biopharma
Specialized Expression–Lessons Learned from Photosynthetic Platforms
Peter B. Heifetz, Ph.D., President & CTO, OrPro Therapeutics, Inc.
Examples of Successful Application of Yeast Expression System for Therapeutic Protein Discovery, Optimization And Production
Piotr Bobrowicz, Ph.D., Director, Technology & Platform Development, Adimab
Additional Sponsored Presentations by