Cambridge Healthtech Institute’s Inaugural
Computational Models for Advancing Biologics
Turning Complex Data into Smarter Biotherapeutic Designs
January 20-21, 2027
As biologics discovery moves from structural prediction toward experimentally validated design, the central challenge is no longer simply generating models but knowing which predictions can guide real therapeutic decisions. CHI’s Inaugural Computational Models for Advancing Biologics will examine how advanced modeling, training data, and computational inputs are being combined to improve the development, design, optimization, validation, and translation of protein therapeutics.
The agenda will explore how reasoning, multimodal, foundation, and specialist models (open and closed) are being applied across sequence, structure, assay, folding, functional, and developability data. Sessions will examine model advances in binding, affinity, epitope engagement, de novo design, protein dynamics, complex biologic formats, and manufacturability, while asking what evidence is needed to move computationally guided candidates toward therapeutic programs. The conference will also address how computationally-guided biologics move toward experimental validation, candidate selection, bioprocess optimization, and manufacturability.
Coverage will include, but is not limited to:
- Reasoning, Multimodal, and Foundation Models
- Open and Closed Models, Consortia Updates
- Modeling Binding, Affinity, and Epitope Mapping
- Functional Data as the Limiting Reagent for Biologics Models
- Therapeutic Data Beyond the PDB: Functional, Proprietary, and Federated Datasets
- Models for de novo Design of Biologics and Protein Therapeutics
- Physics-Informed Models, Co-Folding, and Protein Dynamics
- AI for Complex Biologic Formats
We are also seeking instructors and facilitators to lead the sessions below (in addition to the podium presentations):
- Competitions and benchmarking
- Interactive breakout discussions
- Demonstrations
- One day training seminars
- Working groups
The deadline for priority consideration is July 3, 2026.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: