Cambridge Healthtech Institute’s 3rd Annual
De novo Design of Biologics
Creating Antibodies, Complex Formats, Peptides, and Mini Proteins in Silico
January 19-20, 2027
A revolution in the de novo design of proteins, antibodies, and peptides is being driven by a plethora of in silico tools including RFdiffusion, BindCraft, BoltzGen, Germinal and many more. The capabilities are improving daily and each iteration demands a rigorous validation of the results. CHI’s Third Annual de novo Design of Biologics: Creating Antibodies, Complex Formats, Peptides and Mini Proteins in silico track on January 19-20 at the Third Annual PEGS AI: Reinventing Biologic Development with AI Guided Design, formerly the Biologic Summit, will bring together experts in computational biology, biologic discovery, and AI/machine learning/deep learning to review developments and progress to date in this exciting field through an exploration of the tools available and best practices to apply them for the de novo design of biologics.
Coverage will include, but is not limited to:
- Advances in de novo design of antibodies, peptides, and miniproteins
- Best practices and caveats for the use of open source de novo design tools
- Binding prediction models
- Building interfaces and design environments
- Creating new de novo design models with enhanced capabilities for complex molecules
- Pairing de novo designs with experimental validation
- Reviewing de novo design in the clinic
- Introducing and training de novo algorithms
- Validation and benchmarking of de novo design models
We are also seeking instructors and facilitators to lead the sessions below (in addition to the podium presentations):
- Competitions and benchmarking
- Interactive breakout discussions
- Demonstrations
- One day training seminars
- Working groups
The deadline for priority consideration is July 3, 2026.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: