Cambridge Healthtech Institute’s 18th Annual

Difficult-to-Express Proteins

May 15-16, 2023


What makes a protein difficult to express, produce, and purify? A host of problems including folding, toxicity to hosts, and purification issues, just to name a few. Cambridge Healthtech Institute's 18th Annual Difficult-to-Express Proteins conference examines the challenges encountered by researchers when striving for high-yield production of difficult-to-produce proteins (DTEPs), and the strategies and technologies that have proven successful in overcoming the challenges to harness these particular proteins.  


Coverage will include, but is not limited to:


  • High-yield production of difficult-to-express proteins
  • Membrane proteins (GPCRs, ion channels, etc.)
  • Caspases, proteases, kinases
  • Disulfide-rich proteins
  • Tagged or fused proteins
  • Overcoming misfolding
  • Aggregation
  • Where to express in the cytoplasm, periplasm, or extracellular in the medium?
  • Emerging tools & technologies
  • Case studies


The deadline for priority consideration is October 21, 2022.


All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.


Opportunities for Participation:



For more details on the conference, please contact:

Mary Ann Brown

Executive Director, Conferences

Cambridge Healthtech Institute

Phone: 781-972-5497



For sponsorship information, please contact:

Companies A-K

Jason Gerardi

Senior Manager, Business Development

Cambridge Healthtech Institute

Phone: 781-972-5452



Companies L-Z

Ashley Parsons

Manager, Business Development

Cambridge Healthtech Institute

Phone: 781-972-1340


Register Now

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