Cambridge Healthtech Institute’s 16th Annual
Optimizing Protein Expression
May 12-13, 2026
Efficient recombinant protein production relies on integrated strategies spanning host systems, construct design, folding pathways, and post-translational modifications. Complex proteins, multiprotein assemblies, antibodies, analytes, and mini-proteins each present distinct challenges in folding, stability, and yield. Cambridge Healthtech Insitute’s 16th annual Optimizing Protein Expression conference explores advances in engineering, process optimization, and sustainability, supported by data-driven analytics and automation. Through comparative insights and case studies, experts highlight how integrated expression platforms drive productivity, quality, and scalability from discovery through early development.
Coverage will include, but is not limited to:
- Understanding the requirements of different recombinant protein classes (complex proteins, protein complexes, antibodies, analytes, mini-proteins)
- Capabilities and limitations of diverse expression hosts
- Comparative evaluation of expression systems (microbial, insect, mammalian, cell-free, plant-based)
- Mechanistic insights into protein folding, assembly, and stability across platforms
- Advances in vector design and genetic engineering tools
- Cell line engineering (CLE) and cell line development (CLD) innovations
- Linking upstream expression to downstream process development
- Strategies for faster, more efficient protein production
- Optimizing culture and expression conditions
- Enabling higher throughput through automation and miniaturization
- Data-driven optimization: analytics, modeling, and predictive tools
- Enhancing quality, reproducibility, and productivity in production pipelines
- Case studies highlighting successes and lessons learned
The deadline for priority consideration is October 17, 2025.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: