Cambridge Healthtech Institute’s 17th Annual
Optimizing Protein Expression
Improving the Speed, Yield, and Quality of Protein Expression
May 11-12, 2027
Improving protein production is critical in today’s rapidly advancing protein technology landscape. Different protein classes present distinct challenges in expression, folding, assembly, stability, and solubility, requiring strategies tailored to both the molecule and the production platform. Cambridge Healthtech Institute’s 17th Annual Optimizing Protein Expression conference will focus on advancing protein production from discovery through early development. Topics will include: advances in mammalian and microbial cell engineering, transient and cell-free expression, platform selection, predictive modeling, glycosylation control, sequence and construct design, and data-guided experimentation for faster, scalable, and reproducible protein production.
Coverage will include, but is not limited to:
- Optimizing Protein Expression in Mammalian and Microbial Systems
- Glycan pathway engineering in CHO cells
- Inducible systems for toxic protein production
- Media optimization for glycan quality attributes
- Optimizing expression in microbial hosts
- Predicting Expression before You Build It
- Matching the protein to the host
- Predicting expression success directly from sequence
- Predicting aggregation and solubility from sequence
- Virtual cells and AI construct design
- Closed-loop DBTL workflows in practice
- Transient Expression to Scale: DOE, Platform Selection & CLD-Ready Data
- Stable pool platforms delivering CLD data
- HD CHO, ExpiCHO, and HEK293 comparison
- Aligning discovery- and manufacturing-stage platforms
- Scale translation challenges and DOE strategies
- Cell-Free Expression: Yield, Speed, and Optimization
- Cell-free glycoprotein synthesis with PTMs
- Modular cell free for diverse screening
- Feeding cryo EM workflows via screening
- AI-driven optimization and cost benchmarking
- Product Quality by Design: Engineering Specs, Not Fixing Them Downstream
- Engineering quality during expression, not downstream
- Glycosylation control and high mannose reduction
- Charge variant control and aggregation propensity
- Fragmentation and clipping liabilities in expression
The deadline for priority consideration is October 23, 2026.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation:
- To submit a podium presentation, please click here.
- To become a sponsor, click here.
- To present a poster, click here.
- To sign up to attend, click here.