Plenary Keynote Sessions

Monday, May 11

Plenary Keynote Session

Wednesday, May 13

PEGS Young Scientist Keynote Alumni Panel: Exploring the Perspectives of Next-Generation Innovators on the Future of Protein Science

Moderator:

James A. Wells, PhD, Professor, Departments of Pharmaceutical Chemistry and Cellular & Molecular Pharmacology, University of California, San Francisco

Panelists:

Kathryn Hastie, PhD, Instructor, La Jolla Institute for Immunology

Jamie Spangler, PhD, Associate Professor, Johns Hopkins University

Kipp Weiskopf, MD, PhD, Resident Physician, Brigham and Women’s Hospital

Timothy Whitehead, PhD, Professor, University of Colorado

Xin Zhou, PhD, Assistant Professor, Harvard Medical School

Thursday, May 14

PLENARY FIRESIDE CHAT: How to Think About Designing Smart Antibodies in the Age of GenAI: Integrating Biology, Technology, and Experience

Moderator:

Christopher J. Langmead, PhD, Director of Digital Biologics Discovery, Amgen

Panelists:

Surge Biswas, PhD, Founder & CEO, Nabla Bio, Inc.

Rebecca Croasdale-Wood, PhD, Senior Director, Augmented Biologics Discovery & Design, Biologics Engineering, Oncology, AstraZeneca

Joshua Meier, PhD, Co-Founder, Chai Discovery

Maria Wendt, PhD, Global Head, Preclinical Computational Innovation Strategy Research Platforms, R&D, Sanofi

Michel Sadelain, MD, PhD, Director, Columbia University Initiative in Cell Engineering and Therapy (CICET); Director, Cell Therapy Initiative, Herbert Irving Comprehensive Cancer Center; Professor of Medicine, Columbia University Irving Medical Center
Michel Sadelain, MD, PhD, is the Director of the Center for Cell Engineering and the incumbent of the Stephen and Barbara Friedman Chair at Memorial Sloan Kettering Cancer Center. Dr. Sadelain’s research focuses on human cell engineering and cell therapy to treat cancer and hereditary blood disorders. His laboratory has made several seminal contributions to the field of chimeric antigen receptors (CARs), from design to clinical translation. His group was the first to publish dramatic molecular remissions in patients with chemorefractory acute lymphoblastic leukemia following treatment with CD19 CAR T cells.

James A. Wells, PhD, Professor, Departments of Pharmaceutical Chemistry and Cellular & Molecular Pharmacology, University of California, San Francisco
Wells’s group pioneered the engineering of proteins, antibodies, and small molecules that target catalytic, allosteric, and protein-protein interaction sites; technologies including protein phage display, alanine-scanning, engineered proteases for improved hydrolysis, bioconjugations, N-terminomics, disulfide “tethering” (a novel site-directed fragment-based approach for drug discovery); and more recently an industrialized recombinant antibody production pipeline for the proteome. These led to important new insights into protease mechanisms, growth factor signaling, hot-spots in protein-protein interfaces, role of caspases in biology, and more recently to determining how cell surfaces change in health and disease. His team was integral to several protein products, including Somavert for acromegaly, Avastin for cancer, Lifitegrast for dry eye disease, and engineered proteases sold by Pfizer, Genentech, Shire and Genencor, respectively. He is an elected member of the US National Academy of Science, American Association of Arts and Science, and the National Academy of Inventors.

Kathryn Hastie, PhD, Instructor, La Jolla Institute for Immunology
Dr. Hastie uses high-resolution structural analysis to design better therapeutics and vaccines against viruses that threaten global health. She is a leading expert on the hemorrhagic fever virus Lassa virus and serves on international task forces to steer thought about how to better elicit and detect the right responses to Lassa virus and to deliver a much-needed vaccine to endemic areas. Most recently, Dr. Hastie has worked with the Coronavirus Immunotherapeutic Consortium (CoVIC) to compare leading therapeutics against SARS-CoV-2 and illuminate surfaces on the Spike protein that are less likely to escape antibody-mediated neutralization. Dr. Hastie further spearheads antibody discovery efforts at La Jolla Institute for Immunology to find antibodies against emerging viruses and other therapeutic targets.

Jamie Spangler, PhD, Associate Professor, Johns Hopkins University
Dr. Jamie Spangler earned a Bachelor of Science degree in Biomedical Engineering at Johns Hopkins University and went on to complete a PhD in Biological Engineering at MIT under the supervision of Professor K. Dane Wittrup. She conducted postdoctoral training in Professor K. Christopher Garcia’s lab at Stanford University School of Medicine, and then launched her independent research group at Johns Hopkins University in July 2017, jointly between the departments of Biomedical Engineering and Chemical & Biomolecular Engineering. Dr. Spangler’s lab, located in the Translational Tissue Engineering Center at the School of Medicine, applies structural and mechanistic insights to re-engineer existing proteins and design new proteins that therapeutically modulate the immune response. In particular, her group is interested in engineering immune molecules such as antibodies, cytokines, and growth factors for targeted treatment of diseases such as cancer, infectious diseases, and autoimmune disorders. Dr. Spangler’s work has been recognized with honors including a National Defense Science and Engineering Graduate Fellowship, a Leukemia & Lymphoma Society Career Development Fellowship, a V Foundation Scholar award, and a Maryland Stem Cell Research Fund Discovery award.

Kipp Weiskopf, MD, PhD, Resident Physician, Brigham and Women’s Hospital
Kipp Weiskopf, M.D., PhD, is a Valhalla Fellow at Whitehead Institute for Biomedical Research in Cambridge, MA. He is a leader in the field of macrophage-directed therapies and oversees a research laboratory that studies novel macrophage and myeloid immune checkpoints for the treatment of cancer. Dr. Weiskopf is concurrently appointed as a Hematology and Oncology fellow at Dana-Farber Cancer Institute in Boston, MA. Dr. Weiskopf earned his medical and graduate degrees at Stanford University. As a member of Dr. Irving Weissman’s laboratory, he characterized the CD47/SIRPa interaction as an immune checkpoint that regulates macrophages in cancer. He engineered therapies that stimulate macrophages to attack tumors and showed these could be effective for many types of cancer. Dr. Weiskopf is an inventor on over 15 U.S. patents pertaining to macrophage-directed therapies. He co-founded ALX Oncology, a biotech company that is investigating macrophage-directed therapies in multiple Phase I and II trials for cancer. Other technology that Dr. Weiskopf invented has been licensed to Forty Seven, Inc. (acquired by Gilead). More recently, he co-founded DEM Biopharma to identify novel “don’t eat me” signals that can be targeted for cancer and other life-threatening diseases. Dr. Weiskopf completed his medical training in the Internal Medicine Residency Program at Brigham and Women’s Hospital and is board certified in Internal Medicine. He has previously been awarded a Winston Churchill Scholarship, an NCI Ruth L. Kirschstein NRSA Fellowship, the Harold M. Weintraub Graduate Student Award, and first place in the Collegiate Inventors Competition. Dr. Weiskopf previously earned a B.A. from Amherst College and an M.Phil. in genetics from University of Cambridge.

Timothy Whitehead, PhD, Professor, University of Colorado
Tim Whitehead is an Associate Professor at the University of Colorado, Boulder in the Dept. of Chemical and Biological Engineering. He has won an NSF CAREER award, holds 6 patents (5 licensed), and has published over 50 research articles in journals like Science, Nature Biotechnology, and Nature Methods.

Xin Zhou, PhD, Assistant Professor, Harvard Medical School
Xin Zhou is an Assistant Professor of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, and Cancer Biology, Dana-Farber Cancer Institute. She obtained her PhD in Bioengineering with Dr. Michael Lin from Stanford University and did her postdoctoral training with Dr. Jim Wells at UCSF. Dr. Zhou’s research focuses on engineering functional protein sensors and switches for modulating biology. In the past, she has built proteins with versatile functions, including light-activated enzymes, phosphotyrosine recognition domains, antibody antagonists and agonists, and biosensors to measure SARS-CoV-2 antibodies. Her work was recognized by many awards including an NIH Pathway to Independence Award and a Damon Runyon-Dale F. Frey Award for Breakthrough Scientists. Dr. Zhou’s new research group aims to leverage the power of protein engineering to gain a deeper fundamental understanding of malignancies and to discover new avenues for therapeutic intervention.

Christopher J. Langmead, PhD, Director of Digital Biologics Discovery, Amgen
Christopher James Langmead is the Director of Digital Biologics Discovery at Amgen. His team at Amgen develops and uses AI/ML methods to design and optimize of biologics. He earned his PhD in computer science from Dartmouth and then spent the next 18 years as faculty in computer science and computational biology at Carnegie Mellon University where his group developed a variety of generative models relevant to protein design, including GREMLIN. Dr. Langmead joined Amgen at the beginning of 2022.

Surge Biswas, PhD, Founder & CEO, Nabla Bio, Inc.
Surge is a co-founder and the CEO at Nabla Bio, an antibody design company. Surge received his PhD from George Church’s lab. There, he and his colleagues pioneered the development of protein language modeling, a technology that has been central to state-of-the-art protein structure prediction and machine learning-guided protein design. Outside of Nabla, Surge enjoys hanging out with his wife and Nabla co-founder, Frances, and their two dogs, Archie and Riley.

Rebecca Croasdale-Wood, PhD, Senior Director, Augmented Biologics Discovery & Design, Biologics Engineering, Oncology, AstraZeneca
Rebecca is an innovative leader responsible for the implementation of novel and disruptive in silico technologies to increase the speed of discovery and quality of biologics therapeutics. She is an experienced antibody engineer with structural biology expertise and was co-inventor of the CrossMab technology that is now leading the way in approvals for multi-specific antibody therapeutics. She has authored 30+ patents and publications in the field of antibody engineering.

Joshua Meier, PhD, Co-Founder, Chai Discovery
Joshua Meier is the former Chief AI Officer at Absci, where he spearheaded the company's transformation into AI Drug Discovery and built robust departments of AI scientists and engineers. Under Joshua’s leadership, Absci pioneered groundbreaking generative AI models for the creation of novel protein therapeutics, closed deals with leading biopharmaceutical companies and published work on antibody design, antibody optimization, and codon optimization. Prior to Absci, Joshua was a senior researcher at Facebook AI Research, where he co-founded and led the platform for protein language modeling. At Facebook, Joshua was principal developer of the ESM-1b and ESM-1v models, which are widely utilized across the biopharmaceutical industry. In his earlier roles, Joshua developed language models & reinforcement learning at OpenAI, managed a virtual reality product at Google, and built MIT's CRISPR-ML design platform. Joshua completed his undergraduate and graduate work in computer science & chemistry at Harvard.

Maria Wendt, PhD, Global Head, Preclinical Computational Innovation Strategy Research Platforms, R&D, Sanofi
Biography to be announced