Cambridge Healthtech Institute’s 14th Annual
Biophysical Methods
New Strategies and Technologies for Next Generation Analyses of Complex Biologics
May 12-13, 2026
As biologic pipelines diversify, the need for precise, high-throughput, and predictive characterization tools has never been greater. Cambridge Healthtech Institute's 14th annual Biophysical Methods conference brings together innovators advancing automation, miniaturization, and multimodal analytics to address the unique challenges of today’s complex therapeutics. Topics range from microfluidic assay development and robotic sample handling to in silico modeling of aggregation, viscosity, and stability risks. Presentations will spotlight cutting-edge mass spectrometry, imaging, and AI-powered analysis for everything from viral vectors and LNPs to nanobodies and co-formulations. By blending experimental data with modeling frameworks, this program highlights practical solutions for linking biophysical properties to potency, immunogenicity, and clinical performance—helping researchers de-risk development and accelerate promising candidates toward the clinic.
Coverage will include, but is not limited to:
Automation and Miniaturization
- Assay development for miniaturized/microfluidic methods
- Automated sample preparation and robotic integration for high-throughput analytics
- Data capture and analysis for high-throughput methods
Biophysical Characterization for New Modalities
- Characterization and stability prediction for genetic medicines
- Characterization of co-formulations
- Stability prediction for novel biotherapeutic formats
Modeling and Predicting Biophysical Liabilities
- Data integration frameworks combining modeling and experimental workflows
- In silico prediction of aggregation, viscosity, and particle risks
- Machine learning models for developability linked to wet-lab validation
- Predictive modeling of solubility and colloidal stability
MS Applications and Technologies
- High-throughput MS for intact mass and attribute monitoring
- MAM applications for early development and QC release
- MS characterization of viral vectors, LNPs, and delivery systems
- Multimodal analytics combining MS with biophysical and imaging methods
- Native MS and HDX-MS for higher-order structure characterization
Image Analysis
- Advances in cryo-EM and high-resolution microscopy
- AI-powered tools for automating image interpretation and anomaly detection
- High-throughput imaging platforms for sub-visible particles and morphology analysis
- Mass photometry for LNPs and viral particle characterization
Problems and Solutions
- Analytical strategies for scFvs, nanobodies, and small fragments
- Linking biophysical properties to potency, immunogenicity, and clinical outcomes
- Solutions for high-concentration formulations and viscosity control
- Methods for glycosylation and glycan heterogeneity analysis
The deadline for priority consideration is October 31, 2025.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: