Cambridge Healthtech Institute’s 18th Annual
Predicting Immunogenicity with AI/ML Tools
Transforming Drug Development with Computational Tools
May 12-13, 2026
With the expanding diversity of novel biotherapeutics, the ability to predict and mitigate immunogenicity remains a critical factor in successful drug development. Advances in AI, machine learning, and deep learning are transforming this space, from humanizing antibodies and nanobodies, to mapping epitopes and integrating in silico assessments earlier in discovery. Emerging strategies are also being applied to new modalities such as bispecifics, AAVs, vaccines, and cell and gene therapies, while growing attention is being placed on administration route, molecular mimicry, and regulatory readiness. Join leading industry and academic experts at Cambridge Healthtech Institute’s 18th annual Predicting Immunogenicity with AI/ML Tools conference to explore the latest breakthroughs in applying computational tools to deimmunize high-risk molecules and accelerate biotherapeutic development.
Coverage will include, but is not limited to:
- AI, ML, and deep learning to humanize antibodies, nanobodies, and novel protein scaffolds
- Next-generation prediction tools for T cell and B cell epitopes to de-risk drug development
- Integrating in silico immunogenicity and developability assessments earlier in discovery to accelerate lead selection
- Large-scale epitope mapping and protein language models to improve prediction accuracy
- Applying AI strategies to new modalities including bispecifics, AAVs, vaccines, and cell & gene therapies
- Exploring how route of administration influences immunogenicity risk and patient outcomes
- Regulatory acceptance of AI/ML immunogenicity tools through improved validation and explainability
- Molecular mimicry insights to identify hidden immunogenic hotspots in therapeutic sequences
The deadline for priority consideration is October 17, 2025.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: