Congratulations to the PEGS Boston Summit 2023 Poster Winner

Héctor Sánchez-Morán

Héctor Sánchez-Morán from the University of Colorado, Boulder

Single Molecule FRET Reveals Protein Dual Stabilization Mechanism in an Immobilization Support
Immobilization matrices for biosensor applications may promote protein unfolding via unknown mechanisms. We designed polymeric supports with novel monomers to immobilize enzymes, and we found that these supports dramatically improved protein stability in denaturing conditions. Single molecule FRET protein dynamics study revealed that optimally stabilizing supports promote dual faster refolding and slower unfolding, resulting in more time-averaged folded protein.




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