Training Seminars

Cambridge Healthtech Institute Training Seminars offer real-life case studies, problems encountered and solutions applied, along with extensive coverage of the academic theory and background. Each Training Seminar offers a mix of formal lecture and interactive discussions and activities to maximize the learning experience. These Training Seminars are led by experienced instructors who will focus on content applicable to your current research and provide important guidance for those new to their fields.

TS8A: Introduction to Protein and Antibody Engineering

MONDAY, August 31 - TUESDAY, September 1


8:30 am - 12:30 pm Seminar Sessions
2:20 - 1:30 Problem Solving Breakout Discussions
4:00 - 5:40 Plenary Keynote Session
5:40 - 7:15 pm Welcome Reception in the Exhibit Hall with Poster Viewing


8:30 am - 5:25 pm Seminar Sessions
12:30 - 1:00 pm Lunch Provided

Exhibit Hall Refreshment Breaks also provided.


David Bramhill, PhD, Founder, Bramhill Biological Consulting, LLC



This training seminar offers a comprehensive tutorial in the concepts, strategies and latest tools of protein engineering applied to biotherapeutic research and development, particularly antibody and related products. The class is directed at scientists new to the industry or working in support roles, academic scientists and career protein scientists wanting a detailed update on the current state of the field.

Topics to Be Discussed:

  • Natural protein and antibody diversity
  • Accessing antibody diversity - hybridomas and single cells
  • Humanizing strategies for antibodies
  • Synthetic diversity: Display technologies and library designs
  • Deep sequencing applied to repertoires and libraries
  • Engineering to improve: affinity, specificity, catalytic rate, stability, solubility, serum half-life and reduce immunogenicity
  • Evaluating biotherapeutic developability
  • Manufacturing platforms for antibodies and fragments
  • Emerging product formats: Bispecific antibodies/binders, Antibody-drug conjugates (ADCs), CAR-T and NK cell strategies

Instructor Biography:

Bramhill_DavidDavid Bramhill, PhD, Founder, Bramhill Biological Consulting, LLC

Dr. Bramhill has over 20 years’ experience in biologics, both in large biopharma and startup biotech companies. He has expertise in isolating and improving antibodies using phage display and other display systems and is an inventor on library design for small scaffolds and bi-specific formats. He also has experience in diverse expression systems for producing antibodies, antibody fragments and scaffolds. He has taught numerous technical courses for over 15 years at international conferences and served as a Key Opinion Leader for major BioPharma companies.


Each CHI Training Seminar offers 1.5 days of instruction, refreshment breaks, exhibit hall functions, and lunch for all registered attendees on the full day of the class. Each person registered for the Training Seminar will be provided with a hard copy handbook for the Training Seminar in which they are registered. A limited number of additional handbooks may be available for other delegates. CHI encourages track hopping between conference programs, and we ask that Training Seminars not be disturbed once they have begun. We ask that attendees commit to attending the entire 1.5-day training, and not engage in track hopping once the class has started.